Doctors and scientists have warned for years that over-prescribing antibiotics for trivial complaints or infections caused by viruses which do not respond to antibiotics threatens to lead to the spread of resistance to this critically important class of drugs. It is estimated about 750,000 people die every year from drug-resistant infections and it is feared that, by 2050, this number could reach 10 million and cost more than $100tn to global health services, according to the Union for International Cancer Control.
In addition, they have stressed that the problem is being intensified by the widespread use of antibiotics on farms where they are given to animals – most often pigs and poultry but sometimes also cattle – in order to keep them in poor, basic conditions where disease spreads easily. Scientists have uncovered evidence that dangerous versions of superbugs can spread from pigs to humans. The discovery underlines fears that intensive use of antibiotics on farms is leading to the spread of microbes resistant to them.
The discovery of the link has been made by Semeh Bejaoui and Dorte Frees of Copenhagen University and Soren Persson at Denmark’s Statens Serum Institute and focuses on the superbug Clostridioides difficile, which is considered one of the world’s major antibiotic resistance threats.
“Our finding indicates that C difficile is a reservoir of antimicrobial resistance genes that can be exchanged between animals and humans,” said Bejaoui, who is due to present her study at the European Congress of Clinical Microbiology & Infectious Diseases in Lisbonon Sunday. “This alarming discovery suggests that resistance to antibiotics can spread more widely than previously thought, and confirms links in the resistance chain leading from farm animals to humans.”
C difficile infects the human gut and is resistant to all but three antibiotics in use today. Some strains contain genes that allow them to produce toxins that can trigger gut inflammation and life-threatening diarrhoea in the elderly and in hospital patients. The bacterium is considered one of the biggest antibiotic resistance threats in developed countries. In the US, it caused an estimated 223,900 infections and 12,800 deaths in 2017 and cost the healthcare system more than $1bn.
Margaret Chan, former director general of the World Health Organization. “Antimicrobial resistance is on the rise in Europe and elsewhere in the world,” she said. “We are losing our first-line antimicrobials. Replacement treatments are more costly, more toxic, need much longer durations of treatment, and may require treatment in intensive care units.”
However, medical authorities have pointed out that two-thirds of antibiotics are not used on humans at all but are given as agricultural additives. This is done to stave off illnesses and infections in animals that are being kept in conditions that would otherwise cause disease.
Pigs can pass deadly superbugs to people, study reveals | Antibiotics | The Guardian
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